Biotin-PADRE peptide – AKFVAAWTLKAAA – Immunology – Antigens/Epitotes/Pools/Librairies

Biotin-PADRE peptide is the biotinylated version of PADRE peptide - AKFVAAWTLKAAA which is a universal synthetic peptide binding (MHC)-II receptors that activates antigen specific CD4+ T-cells. Universal Major Histocompatibility Complex (MHC) epitope for CD4+ T-cell recruitment and activation：Pan DR-binding epitope (PADRE) is a universal synthetic peptide binding (MHC)-II receptors,of which Human Leukocyte Antigen (HLA)-DR receptors,present on specific immune cells. This epitope activates antigen specific CD4+ T-cells,while initiating innate immune response (inflammatory cascade). This feature describes PADRE’s ability to act as a Toll-like receptor (TLR) agonist which explains its use as adjuvant in many immunotherapeutic vaccines. In addition,PADRE was also reported as an alternative to more complex carriers,such as KLH/BSA or OVA,for prophylaxis and therapeutic vaccines to increase vaccines’ effectiveness and enable large-scale production. Thanks to its high affinity for 15 of the 16 most common HLA-DR types,PADRE has been presented as a universal approach to control anti-tumor immunity and it is currently investigated for the treatment of toxoplasmosis in people with HLA-A*03 type. Moreover,its ability to bind HLA-DR receptors,despite their extreme polymorphism in the human population,makes it a tool of choice to study autoreactive T-cell responses. IC-PEPTIDE offers the scrambled version,as well as the restricted version of this PADRE peptide. See « PADRE scrambled (AAATLWKAAKFVA) » and « Restricted PADRE peptide – ak(Cha)VAAWTLKAAa-Ahx-C » sections to know the prices.

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