Experimental autoimmune encephalomyelitis kit – Multiple sclerosis peptides

IC-PEPTIDE offers a turnkey solution for multiple sclerosis (MS) studies with an experimental autoimmune encephalomyelitis kit (EAE kit). Each kit provided allows the induction of EAE in 9 mice (0.2mL/mouse). The kit contains 2.1mL of a ready-to-use MOG35-55/CFA emulsion,one vial containing 5µg pertussis toxin (PTX) in glycerol buffer and a recommended experimental protocol with typical results. Myelin Oligodendrocyte Glucoprotein (MOG35-55) is used in emulsion with Complete Freund's Adjuvant (CFA) in EAE studies. Emulsification is an important step in the success of the EAE induction,results will partially depend on this phase. SB-PEPTIDE offers a ready-to-use MOG35-55/CFA emulsion. The complete Freund's adjuvant is used as an immunopotentiator,it is composed of inactivated and dried mycobacteria and used with MOG 35-55 to induce EAE. Experimental autoimmune encephalomyelitis is the model commonly used to study efficacy of drugs for treatment of multiple sclerosis (MS) but also pathogenesis of autoimmunity,CNS inflammation,demyelination,cell trafficking and tolerance induction.

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