Human MOG Peptides Pool – Multiple sclerosis peptides

MOG peptides pool for antigen-specific CD4+ and CD8+ T-cells stimulation. Multiple sclerosis (MS) is a condition in which autoimmune cells wrongly attack the layer,surrounding and protecting the nerves,called myelin sheath. The inflammatory substances released by autoreactive T-cells,specific for myelin antigens,such as Myelin Oligodendrocyte Glycoprotein (MOG),damage and scar the sheaths,as well as the oligodendrocytes (myelinating cells of the CNS) and underlying nerves,eventually. The destruction of the insulating material,aiming to preserve the action potential passing through the axon of the neuron,consequently leads to signal slowdown and disruption. Human MOG (UniProtKB - Q16653) is part of the 15-30% proteins constituting the myelin sheath. Even though its primary role is not yet known,its structural features suggest its function as "adhesion molecule" that would be necessary for the structural integrity of the myelin sheath. Besides,its involvement in the completion and/or maintenance of cell-cell communication was hypothesized. IC-PEPTIDE's MOG pool has been developed for specific stimulation of antigen-specific CD4+ and CD8+ T-cells in vitro. IC-PEPTIDE offers Myelin Oligodendrocyte Glycoprotein pool composed of 59 15-mer sequences with 11 amino acids overlap,covering the entire sequence of the human protein. MOG pool is 100% made in France with an average purity of peptides around 70%. The company ensures a strict control of production with batch-to-batch reproducibility to deliver endotoxin free aliquots,verified by LAL. Incubation of Peripheral Blood Mononuclear Cells (PBMC) with SB-PEPTIDE's MOG pool leads to the secretion of effector cytokines and upregulation of activation markers to detect and isolate myelin-specific T-cells. After stimulation,CD4+ and CD8+ T-cells can be used for various applications,including: 1.The detection and analysis of MOG-specific T-cells in PBMC (visit our PBMC Isolation Protocol webpage); 2.The isolation of viable MOG-specific CD4+ and CD8+ T-cells for generation of T-cell lines by expansion; 3.The generation of MOG-specific effector/memory T-cells from naive T-cells; 4.The pulsing of antigen-presenting cells (APC).

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