LL37 - Human cathelicidin peptide – Antimicrobial Peptides – AMP

LL-37 peptide,also known as CAP-18 for Cathelicidin antimicrobial peptide 18,is a 37 amino acid cationic peptide. LL37 is also a typical linear antimicrobial peptide which can eliminate a wide range of pathogenes,including bacteria,viruses,fungi,and parasites. CAP-18 is the only human cathelicidin peptide reported yet,found in lysosomes of macrophages and leukocytes. LL-37 plays an important role in the first act of defense against local infection and systemic invasion of pathogens at sites of inflammation. CAP-18 shows cytotoxicity against bacterial and normal eukaryotic cells and is significantly resistant to proteolytic degradation. Besides its antimicrobial functions,CAP-18 also has immunomodulatory roles. LL37 suppresses the production of pro-inflammatory cytokines,TNF-α and IL-6 in infected monocytes. CAP-18 increases cytokine and chemokine liberation from local cells and leucocytes and has chemotactic effects on a large number of immune cells. IC-PEPTIDE offers the scrambled version of LL-37 peptide (see section "Scrambled LL-37 peptide").

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