MOG (35-55), human peptide – Multiple sclerosis peptides

MOG 35-55 human is a fragment of the human protein MOG (Myelin Oligodendrocyte Glycoprotein - UniProtKB - Q16653),a minor constituent of the myelin sheath. The main role of MOG is to surround neurons and axon to provide efficient action on the potential electrical conduction. The fragment 35-55 from MOG protein is able to induce a model of demyelinating of the myelin sheath : EAE (Experimental autoimmune encephalomyelitis). Induction of EAE will lead to a production of polyclonal anti-MOG 35-55 antibodies and an extensive B cell reactivity against the myelin. Widespread autoimmune response damages the myelin sheath and lead to the Multiple Sclerosis model. Mouse and human MOG35-55 (mouse MOG35-55,reference SB023) differ at position 8 with respectivelly a serine and a proline. This difference attenuates the encephalitogenicity of the human MOG35-55. However,human MOG 35-55 was immunogenic,inducing proliferation and IFN-γ and IL-3 in humans,but not rodents MOG35-55. Nevertheless,when treated by human MOG35-55,rodents are affected by EAE,which means that there are two mechanisms. One mechanism with an encephalitogenic T-cell response to rodent MOG 35-55 and one with an encephalitogenic B-cell response to human MOG epitopes that most likely cross-react with the mouse determinants.

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