MOG (97-108) peptide TCFFRDHSYQEE – Multiple sclerosis peptides

MOG (mouse myelin oligodendrocyte glycoprotein - UniProtKB - Q61885) is an integral membrane protein type I that is important in mouse models of demyelinating disease like EAE (Experimental Autoimmune Encephalomyelitis). Demyelination causes the loss or destruction of the protective sheath around nerves. The myelin oligodendrocyte glycoprotein is widely expressed to the external surface of the peripheral lamellae of myelin sheaths of the CNS (Central Nervous System). The peptide MOG (97-108) is a fragment of the myelin oligodendrocyte glycoprotein (MOG). The immunization in the HLA-DR4 transgenic mice by the MOG 97-108 epitope provokes an immune response by the B cell. This process is a marker of the induction of the MHC II antigen presentation pathway. The MOG 97-108 immunization induces an Experimental Autoimmune Encephalomyelitis (EAE) in mice. This HLA-DR4-restricted epitope increases IFN-γ production of T cells and induces also an EAE (Experimental Autoimmune Encephalomyelitis) in mice immunized by this peptide.

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