MOG (92-106) peptide DEGGYTCFFRDHSYQ – Multiple sclerosis peptides

MOG (Mouse Myelin oligodendrocyte glycoprotein - UniProtKB – Q61885) is a protein with a molecular weight around 26-28 kDa,located on the external surface of the peripheral lamellae of myelin sheaths of the CNS (Central Nervous System). Myelin oligodendrocyte glycoprotein (MOG) is an integral membrane glycoprotein type I of the immunoglobulin family (Ig) found exclusively in mammals. This peptide is a fragment of amino acids 92-106 from Myelin oligodendrocyte glycoprotein (MOG). The MOG 92-106 peptide can be used to induce the production of polyclonal anti-MOG 92-106 antibodies. The epitope MOG (92–106) is a DR4-restricted Th cell epitope and a target for demyelinating auto-antibodies. The demyelinating of the myelin sheaths leads to EAE (Experimental Autoimmune Encephalomyelitis) that develops an extensive B cell reactivity against secondary myelin antibodies. MOG can induce Experimental Autoimmune Encephalomyelitis in mouse strain SJL/L like the MOG (35-55) and induces a widespread autoimmune response. The peptide can also induce myelin disease in DA rats and rhesus monkeys. MOG 92-106 is routinely used in vivo biological evaluation and immunological studies of the Experimental Autoimmune Encephalomyelitis thanks to their high specificity and affinity,they could be used for peptide-coated ELISA and Western-Blot Assay. The encephalitogenic T cells recognize MOG and some of its immunodominant epitope like MOG (92-106) and induce EAE model that can help to elucidate the immunopathological mechanism of MS (multiple sclerosis).

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