MOG (91-108) peptide SDEGGYTCFFRDHSYQEE – Multiple sclerosis peptides

MOG (Myelin Oligodendrocyte Glycoprotein - UniProtKB - Q61885) is a protein with a molecular weight of around 26-28 kDa,located on the external surface of the peripheral lamellae of myelin sheaths of the CNS (Central Nervous System). MOG is an important antigenic target in autoimmune diseases that mediates demyelination in the CNS. This peptide is a fragment of amino acids 91-108 from Myelin oligodendrocyte glycoprotein (MOG). MOG (91-108) peptide contributes to multiple signaling pathways in lymphocytes as well as in organ-resident cells like in the CNS. MOG 91-108 is a one of the major determinant to trigger disease in rats expressing RT1av1 or RT1n haplotypes. Moreover,in MOG 91-108-induced EAE (Experimental Autoimmune Encephalomyelitis) the interaction of CXCR4 and CXCL12 is of paramount importance for disease development. Therefore MOG91-108 upregulate the activity of the chemokine receptor CXCR4 and its ligand CXCL12.

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