Neuropeptide RFRP-3 (124-131) – Neuroscience Peptides

Neuropeptides are small signaling molecules produced and released by neurons engaged in many physiological functions. Indeed,neuropeptides act on neural substrates such as G protein-coupled receptors (GPCRs),tyrosine-kinase receptors,insuline-like peptides and also ion channels. Actions of neuropeptides result in slow-onset,long-lasting modulation of synaptic transmission. Pro-FMRFamide-related neuropeptide VF also called neuropeptide VF precursor are expressed in neurons in mediobasal hypothalamus. Neuropeptide VF precursor is a propeptide which is cleaved in three others peptide: Neuropeptide RFRP-1,RFRP-2 and RFRP-3. Neuropeptide RFRP-3 acts as a potent synthesis and secretion gonadotropin inhibitor. Neuropeptide RFRP-3 inhibit forskolin-induced production of cAMP and progesterone production in human cells. Neuropeptide RFRP-3 (124-131) is a part of RFRP-3 and is useful in opioid research.

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