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Alpha-Casozepine – Neuroscience Peptides

Alpha-Casozepine (alpha-CZP) is a tryptic hydrolysate of bovine milk alphas1-casein. The presence of bile salts facilitates alpha-CZP absorption through a Caco2 monolayer. alpha-CZP shows similarities to benzodiazepines with its anxiolytic-like activity but lack the common side effects of habituation or sedation. alpha-CZP binds to the GABAA receptor at the benzodiazepine site. alpha-CZP binds with a significantly lower affinity than benzodiazepines. Intraperitoneal administration of Alpha-Casozepine (alpha-CZP) to rodents results in anticonvulsant and sleep-protecting effects. Human administration reduces physiological stress symptoms in stressed and control patients. alpha-CZP modulated neuronal activity in brain regions linked to anxiety regulation in mice.

Technical specification

SequenceH-YLGYLEQLLR-OH
MW1.266.7 g/mol
Purity> 95%
Counter-ionTFA Salts
Delivery formatLyophilized

Price

ProductSizePrice €Price $
CRB1001691-0.5 mg0.5 mg141 €170 $
CRB1001691-1 mg1 mg193 €232 $